NADP+, DISODIUM SALT
Triphosphopyridine nucleotide, disodium salt
CAS: 24292-60-2
Molecular Formula: C21H26N7Na2O17P3
NADP+, DISODIUM SALT - Names and Identifiers
| Name | Triphosphopyridine nucleotide, disodium salt |
| Synonyms | NADP, NA2 COENZYME II BETA-NADP-NA2 NADP disodium salt NADP, DISODIUM SALT NADP+, DISODIUM SALT BETA-NADP DISODIUM SALT NADP, Disodium Salt (1.24541) Triphosphopyridine nucleotide, disodium salt beta-Nicotinamide adenine dinucleotide phosphate disodium salt BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DISODIUM SALT B-NICOTINAMIDE ADENINE DINUCLEOTIDE 3'-PHOSPHATE, DISODIUM SALT NADP, disodium salt !-Nicotinamide adenine dinucleotide phosphate, disodium salt |
| CAS | 24292-60-2 |
| EINECS | 246-129-8 |
| InChI | InChI=1/C21H28N7O17P3.2Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32;;/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,39);;/q;2*+1/p-2/t10-,11-,13-,14-,15-,16-,20?,21-;;/m1../s1 |
| InChIKey | UNRRSQIQTVFDLS-WUEGHLCSSA-L |
NADP+, DISODIUM SALT - Physico-chemical Properties
| Molecular Formula | C21H26N7Na2O17P3 |
| Molar Mass | 787.37 |
| Density | 1.66g/cm3 at 20℃ |
| Melting Point | 175-178 °C |
| Water Solubility | >50 g/L |
| Solubility | Very easy to absorb moisture, soluble in water, methanol, slightly soluble in ethanol, almost insoluble in ether and ethyl acetate |
| Vapor Presure | 0.002-0.004Pa at 20-25℃ |
| Appearance | Powder |
| Color | Yellow |
| Odor | Odorless |
| PH | 4.0 ± 1.0(10mg/mL) |
| Storage Condition | -20°C |
| Sensitive | Sensitive to heat |
| MDL | MFCD00065390 |
| Use | This product is for scientific research only and shall not be used for other purposes. |
NADP+, DISODIUM SALT - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S37/39 - Wear suitable gloves and eye/face protection S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-21 |
| HS Code | 29349990 |
NADP+, DISODIUM SALT - Reference
| Reference Show more | 1. [IF=6.054] Zhao Chen et al."Novel 1,3,4-Selenadiazole-Containing Kidney-Type Glutaminase Inhibitors Showed Improved Cellular Uptake and Antitumor Activity."J Med Chem. 2019;62(2):589–603 2. [IF=3.575] Wei Hou et al."Propylselen inhibits cancer cell growth by targeting glutamate dehydrogenase at the NADP+ binding site."Biochem Bioph Res Co. 2019 Jan;509:262 3. [IF=3.216] Guifang Jin et al."Mutagenic Activity of N-Nitrosodiethylamine in Cell Lines Expressing Human CYP2E1—Adequacy of Dimethylsulfoxide as Solvent."Environ Mol Mutagen. 2019 Apr;60(3):214-226 4. [IF=4.22] Zheng Shanshan et al."NADPH-guided synthesis of iodide-responsive nanozyme: synergistic effects in nanocluster growth and peroxidase-like activity."J Mater Sci. 2021 Mar;56(7):4909-4921 |
NADP+, DISODIUM SALT - Introduction
Enzyme activity diagnostic reagents and components of complex coenzymes.
Last Update：2022-10-16 17:15:12
NADP+, DISODIUM SALT - Reference Information
| LogP | -4.4 at 20℃ and pH7 |
| surface tension | 73.2mN/m at 1g/L and 20 ℃ |
| introduction | beta-nicotinamide adenine dinucleotide disodium phosphate is a white or white-like solid, which is a coenzyme substance. NADP disodium for enzymatic preparation of 2, 4-diaminobutyric acid. |
| Mechanism of action | β-nicotinamide adenine dinucleotide NAD and β-nicotinamide adenine dinucleotide phosphate NADP are necessary for cell energy metabolism Coenzymes play a central role in energy metabolism. In addition, purine nucleotides also play an important role in biological processes. Protons in energy reactions are usually first transferred to NAD and NADP, and then reduced to NADH and NADPH, which are transferred to oxygen through electrons and release energy. The resulting reduced NADH and NADPH are coenzymes of glutathione reductase and have important antioxidant functions. |
| detection method | a method for measuring the content of β-NADP disodium salt and related substances, the related substances are NAD, ATP and ADP, and are characterized by the following steps: a, taking sigma reference substance: beta-nicotinamide adenine dinucleotide phosphate disodium salt is dissolved into a reference substance solution with a concentration of 1 mg/ml by diluent; take a sample of beta-nicotinamide adenine dinucleotide disodium phosphate and dissolve it with diluent into a sample solution with a concentration of 0.5 mg/ml; B, take 20ul of the reference substance solution and 20ul of the sample solution respectively, inject it into a liquid chromatograph, record the peak area of beta-nicotinamide adenine dinucleotide disodium phosphate in the chromatogram, and calculate the HPLC content with anhydrous beta-nicotinamide adenine dinucleotide disodium phosphate according to the external standard method, not less than 98%;C, take sigma reference substances NAD, ATP and ADP respectively and dissolve them into impurity reference substance solutions with concentrations of 5ug/ml, 2.5ug/ml and 2.5ug/ml respectively with mobile phase, take beta-nicotinamide adenine dinucleotide disodium phosphate sample and dissolve them into sample solution with concentration of 0.5 mg/ml with mobile phase; D take 20ul of NAD, ATP and ADP impurity reference substance solutions respectively, inject into liquid chromatograph, record the peak areas of NAD, ATP and ADP in chromatogram, and then calculate the contents of NAD, ADP and ATP in beta-nicotinamide adenine dinucleotide disodium phosphate samples according to external standard method, of which NAD, ADP and ATP are not more than 1.0%, 0.5% and 0.5% respectively. |
| Biological activity | Triphosphopyridine nucleotide (NADP) can alternate oxidation and switching states between NADP and NADPH, and is an electronic carrier in many biological reactions. |
| use | nicotinamide adenine dinucleotide phosphate (NADP) and NADPH form redox pairs. NADP / NADPH is a coenzyme that supports redox reactions through electron transport, especially anaerobic reactions such as lipid and nucleic acid synthesis. NADP / NADPH is a coenzyme that couples various cytochrome P450 systems and oxidase/reductase reaction systems, such as the coenzyme of the thioredoxin reductase/thioredoxin system. |
Last Update：2024-04-09 20:52:54
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